Observe Closely (1)pentobarbital will lower the level or outcome of hydrocodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Observe Intently. Warning when discontinuing CYP3A4 inducers which have been coadministered with hydrocodone; plasma concentrations of hydrocodone may perhaps improve and can result in likely deadly respiratory depressionSerious - Use Choice (1)hydrocodone, pentobarbital.
Parenteral methods of barbiturates are hugely alkaline; Serious treatment need to be taken to stay away from perivascular extravasation or intra-arterial injection; extravascular injection may well lead to area tissue injury with subsequent necrosis; effects of intra-arterial injection may well differ from transient agony to gangrene from the limb; any grievance of suffering in the limb warrants halting the injection
pentobarbital will decrease the extent or result of pazopanib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.
Monoamine oxidase inhibitors (MAOI) may well inhibit barbiturate metabolism and extend barbiturate effects; check closely
pentobarbital will lessen the level or result of zolpidem by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Not known.
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pentobarbital will lessen the extent or outcome of bortezomib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.
pentobarbital will reduce the level or impact of roflumilast by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Coadministration not proposed; strong cytochrome P450 enzyme inducers decrease systemic exposure to roflumilast and could lessen the therapeutic usefulness
pentobarbital will reduce the extent or outcome of nateglinide by affecting hepatic enzyme CYP2C9/10 metabolism. Use Caution/Watch.
pentobarbital will reduce the level or result of atorvastatin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch.
With therapeutic doses of TCAs, barbiturates increase metabolism and reduce blood concentrations of TCAs.
pentobarbital decreases amounts of vandetanib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Stay away from coadministration with potent CYP3A4 inducers; these drugs cut down publicity to vandetanib by nearly forty%.
pentobarbital will lower the extent or influence of ethinylestradiol by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Keep away from or Use Alternate Drug. The efficacy of hormonal contraceptives may be decreased. Use of a nonhormonal contraceptive is suggested.
pentobarbital will minimize the extent or result of isradipine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Importance Mysterious.